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Ac-IETD-CHO (Ac-Ile-Glu-Thr-Asp-CHO)
| 貨號 | IAP1211 | 售價(jià)（元） | 1235 |
| 規(guī)格 | 1mg | CAS號 |
- 產(chǎn)品簡介
- 相關(guān)產(chǎn)品
|
貨號 |
名稱 |
規(guī)格 |
價(jià)格 |
|
IAP1211-0001MG |
Ac-IETD-CHO |
1MG |
1235 |
|
IAP1211-0005MG |
Ac-IETD-CHO |
5MG |
3920 |
產(chǎn)品簡介：
Ac-IETD-CHO是胱天蛋白酶-8的抑制劑(IC50 = 5 nM)。[1]當(dāng)以60 μM的濃度使用時(shí)，它抑制丙酸氟替卡松誘導(dǎo)的哮喘患者外周血T細(xì)胞凋亡增加。[2] Ac-IETD-CHO (10 mg/kg)抑制Fas誘導(dǎo)的凋亡和肝衰竭小鼠模型中肝臟胱天蛋白酶-3活性、DNA片段化、胞質(zhì)細(xì)胞色素c水平和胱天蛋白酶-3、-8和-9酶原蛋白水解加工的增加。[3]
產(chǎn)品性質(zhì)：
別名:Caspase-8 Inhibitor
化學(xué)名:N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-threoninamide, trifluoroacetate salt
Canonical SMILES: C[C@@H](O)[C@@H](C(N[C@@H](CC(O)=O)C=O)=O)NC([C@@H](NC([C@H]([C@@H](C)CC)NC(C)=O)=O)CCC(O)=O)=O.FC(F)(C(O)=O)F
分子式:C21H34N4O10 ? XCF3COOH
分子量:502.5
溶解度:1mg/mL in water
儲存條件:Store at -20°C
注意事項(xiàng)：
為了您的安全和健康，請穿實(shí)驗(yàn)服并戴一次性手套操作。
References:
[1]. Smith, G.K., Barrett, D.G., Blackburn, K.J., et al. Expression, preparation, and high-throughput screening of caspase-8: Discovery of redox-based and steroid diacid inhibition. Arch. Biochem. Biophys. 399(2), 195-205 (2002).
[2]. Pace, E., Gagliardo, R., Melis, M., et al. Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma. J. Allergy. Clin. Immunol. 114(5), 1216-1223 (2004).
[3]. Bajt, M.L., Lawson, J.A., Vonderfecht, S.L., et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: Evidence for a postmitochondrial processing of caspase-8. Toxicol. Sci. 58(1), 109-117 (2000)