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Fx1A Antibody
| 貨號 | WB0065M | 售價（元） | 4800 |
| 規(guī)格 | 100ul | CAS號 |
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Background
FBXO15, also known as FBX15, is a 434 amino acid protein that contains one C-terminal F-box domain and belongs to the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO15 can directly interact with Skp1 p19 and CUL-1. In addition, FBXO15 is a target of the transcription factor Oct-3/4, however, it does not appear to be essential for early development and fertility.
Alternative Names收起
gp330; RTEα5; LRP2_RAT; Low-density lipoprotein receptor-related protein 2; LRP-2; Glycoprotein 330; Megalin.
Reactivity收起
Human,Mouse,Rat
Application收起
IHC,IF
Recommend Dilutions收起
IHC 1:100-500,IF 1:100-500
Application Image收起
- IF
- IHC-P
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Paraformaldehyde-fixed, paraffin embedded at[1:500] for 40 minutes and DAPI staining of the nuclei.
Mol Weight收起
518kD
Gene ID收起
201456
UniProt收起
Q8NCQ5
Uniprot link收起
Subcellular location收起
Cell membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Cytoplasm. Note=Expressed in clathrin-coated pits, a soluble form is possibly derived by cleavage at the cell surface.
Specificity收起
Epithelial cells of kidney glomerulus and proximal tubule, lung, epididymis, yolk sac, among others.
Immunogen收起
Fx1A protein
Source收起
Rabbit
Clonality收起
Polyclonal
Isotype收起
IgG
Purification收起
affinity purified by Protein A
Formulation收起
Liquid
Buffer收起
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition收起
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
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