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    細(xì)胞毒霉素是一種可滲透進(jìn)入細(xì)胞的真菌代謝產(chǎn)物，可以抑制肌動(dòng)蛋白聚合。這會(huì)干擾諸如細(xì)胞運(yùn)動(dòng)、生長(zhǎng)、吞噬作用、顆粒釋放和分泌等多種過程。其中，細(xì)胞松弛素D是一種可滲透進(jìn)入細(xì)胞的抑制劑，它能夠結(jié)合肌動(dòng)蛋白絲而不是單體肌動(dòng)蛋白，在低至0.2微米的濃度下抑制聚合反應(yīng)。通過這種方式，它可以阻止腫瘤細(xì)胞的遷移。

產(chǎn)品性質(zhì)：

Cas No.：22144-77-0

別名：細(xì)胞松弛素D; Zygosporin A; NSC 209835

化學(xué)名： (3S,3aR,4R,6R,6aS,7E,10R,12S,13Z,15R,15aS)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate

Canonical SMILES： O[C@@H]1[C@@H](/C=C/C[C@@H](C)C2=O)[C@]3([C@@H](C=C[C@]2(C)O)OC(C)=O)[C@@H]([C@@H](C)C1=C)[C@H](CC4=CC=CC=C4)NC3=O

分子式：C30H37NO6

分子量：507.63

溶解度：10mg/mL in dichloromethane,100 mg/ml in DMSO

儲(chǔ)存條件：Store at -20°C, protect from light

注意事項(xiàng)：

為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并戴一次性手套操作。

Reference:

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[5]. Flaumenhaft, R., Dilks, J.R., Rozenvayn, N., et al. The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretion. Blood 105(10), 3879-3887 (2005).

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[7]. dos Santos, T., Varela, J., Lynch, I., et al. Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines. PLoS One 6(9), 1-10 (2011).

[8]. Nightingale, T.D., White, I.J., Doyle, E.L., et al. Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. Journal of Cell Biology 194(4), 613-629 (2011).

[9]. Hayot, C., Debeir, O., Van Ham, P., et al. Characterization of the activities of actin-affecting drugs on tumor cell migration. Toxicology and Applied Pharmacology 211, 30-40 (2006).